Search results for "Molecular biology" - uOttawa Experts

Full professor
Faculty of Medicine
Biochemistry, Microbiology and Immunology

Contact information:

Office: 6135625800 x 6371
Office: 6135625800 x 6375
Cell: 613 804 1885
Home: 613 518 7767
E-mail: altosaar@uOttawa.ca
Website

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New breeding techniques to fight global warming through climate-smart crops. Climate change, Greenhouse Gases, GHG, Global warming, carbon dioxide, CO2, Nitrous oxide, N2O, bioremediation, biotechnology, soil metagenome, soil microbiome, biodiversity, gene amplification, soil biocatalysts, Atmospheric phytoremediation, Pseudomonas nautica, Marinobacter hydrocarbonoclasticus, nosZ gene operon, Nitrous Oxide reductase enzyme, fertilizer, Nitrogen cycle, nitrate run-off,

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English and French , Estonian Greek German

Senior Scientist
Full professor
Faculty of Medicine
Biochemistry, Microbiology and Immunology

Contact information:

Office: 613-737-7700 (70333)
E-mail: jbell@ohri.ca

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E-mail

Research information:

My lab is defining at the molecular level, the differences between normal and tumour tissues. Our plan is to develop novel cancer therapeutics that target tumour tissue but do not harm normal tissue. We are developing viruses that can infect and kill tumour cells but do not infect normal cells. These viruses are called Oncolytic Viruses

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Associate professor
Faculty of Medicine
Biochemistry, Microbiology and Immunology

Contact information:

Office: 613-562-5800 (8463)
E-mail: alexandre.blais@uottawa.ca
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E-mail

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Our research group studies how the control of gene expression determines cell identity. In particular, we aim at understanding how certain proteins regulate gene transcription in skeletal muscle stem cells during regeneration. To this end, we use an approach called functional genomics, where we study at the scale of the entire genome how proteins interact among each other and with DNA to control gene expression.

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Emeritus professor
Faculty of Medicine
Biochemistry, Microbiology and Immunology

Contact information:

Office: 613 562 5800 x8299
Home: 613 224 7533
E-mail: ebrown@uOttawa.ca

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E-mail

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Virology and microbiology are my specialties. My main activities are on viral genetics and evolution mainly directed at understanding how viruses cause disease (pathogenesis) or become adapted to new hosts. The mechanism used by influenza virus to control the antiviral interferon response. Experience with several viruses, hepatitis C, reovirus, mumps virus, Torque Tino virus (TTV).

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Associate professor
Faculty of Health Sciences
School of Human Kinetics

Contact information:

Office: 562-5800 ext.6987
E-mail: mdelisio@uottawa.ca

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E-mail

Research information:

Work in my lab focuses on the effects of exercise and nutrition on blood and muscle forming stem cells.

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Support staff member
Faculty of Science

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Office: 6139790751
E-mail: Shahrokh.Ghobadloo@uottawa.ca

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E-mail

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My main current activity at Flow Cytometry and Robotic Facility of Cellular Imaging and Cytometry Facility (CICF) is providing service to research groups inside and outside the University of Ottawa. I have researched in the field of Molecular biology, molecular interactions, viruses, genetics, cancer, and clinical biochemistry.

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Molecular biology

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Senior Scientist
Full professor
Faculty of Medicine
Biochemistry, Microbiology and Immunology

Contact information:

Office: 613-737-7700 x70331
E-mail: dgray@ohri.ca
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E-mail

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My laboratory studies the molecular biology of aging and diseases associated with aging (neurodegenerative diseases and cancer). Our primary focus is on the role of declining protein degradation efficiency in aging. Our research makes extensive use of transgenic mouse models, cell culture systems, and live cell imaging.

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Full professor
Faculty of Social Sciences
School of Psychology

Contact information:

Cell: 819-384-3424
E-mail: nafissa.ismail@uottawa.ca
Website

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E-mail, Cell Telephone

Research information:

Understanding the different COVID-19 variants and their impact on our society and children.
Effects of enduring stress (like the COVID-19 pandemic and sanitary restrictions) on brain health.
Mechanisms of sex differences in psychological and neurological illnesses.
Sex differences in COVID-19 symptoms and in the prevalence of long-COVID.
Impact of chronic stress in adolescences.
Building resilience to stress.
The link between the gut microbiome and brain functioning.

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Canada Research Chair in Molecular Virology and Intrinsic Immunity
Assistant professor
Faculty of Medicine
Biochemistry, Microbiology and Immunology

Contact information:

E-mail: langlois@uOttawa.ca
Website

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E-mail

Research information:

HIV, Retroviruses and Immunity

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Assistant professor
Faculty of Medicine
Biochemistry, Microbiology and Immunology

Contact information:

Office: 613-562-5800 (8868)
Cell: 613-851-8781
E-mail: seunglee@uOttawa.ca

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E-mail

Research information:

Although there are many immune system responses against viral infections, Natural Killer (NK) cells are unique because of their rapid anti-viral responses to infections in comparison to other immune cells. My research is focusing on identifying and defining the involvement of natural killer (NK) cells during chronic viral infections. We are integrating multiple disciplines to investigate what NK cells can do during chronic viral infection and to find new insights for treatment.

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Assistant professor
Faculty of Science
Biology

Contact information:

Office: 613-302-6611
E-mail: jan.mennigen@uottawa.ca

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E-mail, Office Telephone

Research information:

Comparative Physiology of Metabolism ? ?I principally use two teleost research models, zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss) to comparatively study energy metabolism, using an integrated approach. This approach covers molecular, cellular and organismal aspects of energy metabolism, all of which integratively form the metabolic phenotype. A current research focus lies on the elucidation of epigenetic origins of metabolic phenotypes across ontogeny and generations, which in contrast to mammalian research models remains largely uncharacterized in lower vertebrates. In addition to providing comparative insight into epigenetic mechanisms governing the metabolic phenotype, the study of epigenetic mechanisms in fish models is especially applicable to three major areas addressed under this framework, which are outlined below. 1) Aquaculture In addition to being a valuable research model in the comparative physiology of metabolism, rainbow trout are the most important aquaculture species in Ontario. Following the recent sequencing of the rainbow trout genome, novel possibilities exist to address regulation and function of context-dependent epigenetic mechanisms in the metabolic phenotype. Focusing primarily on microRNAs, I am interested in how these molecular epigenetic mechanisms contribute to the metabolic phenotype in rainbow trout across ontogeny and at different levels of biological organization. In addition to providing insight into the evolution of microRNA mediated metabolic networks and function, the elucidation of these mechanisms will provide novel insight into the contribution of epigenetic mechanisms to rainbow trout specific phenotypes relevant to aquaculture. Examples include the implication of epigenetic mechanisms in mediating acute and sustained metabolic and growth effects of plant-based diets and the potential implication of epigenetic mechanisms in nutritional programming approaches. 2) Ecotoxicology Principally using the zebrafish model, Danio rerio, I am interested in the role of endocrine disrupting chemicals on the metabolic phenotype across ontogeny and generations either at baseline or in conjunction with environmental stressors experienced across ontogeny and generations. This represents an environmentally realistic scenario, as contaminants are subject to temporal variation due to regulation and continuing emergence of novel aquatic environments. A principal goal is to gain insight into germ-line dependent epigenetic mechanisms (principally DNA methylation) in the emergence of these phenotypes, and to develop epigenetic markers as improved prediction tools for EDC and aquatic contaminant exposure. 3) Teleost fish as models for metabolic disease ? Zebrafish are increasingly used as model systems for disease including metabolic disease. Taking advantage of this model, a specific research interest lies in the elucidation of transgenerational interaction of non-exclusive biological hypothesis of metabolic disease. A principal aim is to gain understanding of the integration of the three major biological hypothesis across ontogeny and generations in the emergence of metabolic disease: (1) The developmental origin of disease hypothesis ('Barker hypothesis') (2) the contribution of environmental endocrine disrupting chemicals ('metabolic disruptor hypothesis') (3) nutritional factors ('life-style hypothesis') This approach is aimed to gain insight into novel epigenetic determinants and the identification of novel molecular drug targets for metabolic disease.

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English and French , German

Senior Scientist & Director
Full professor
Faculty of Medicine
Medicine

Contact information:

Office: 613-739-6740
E-mail: mrudnicki@ohri.ca

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E-mail

Research information:

We are interested in how genes regulate the function of stem cells. In particular, we work to identify the regulatory networks that regulate stem cell growth and regulate cellular differentiation.

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Prof., Pharmacist and PhD candidate in Genetics of Cardiovascular Diseases
Part-time professor
Faculty of Health Sciences
Medicine

Contact information:

Office: 613-255-5476
Cell: 613-255-5476
Home: 613-255-5476
E-mail: mshehata@ottawaheart.ca

Preferred method of contact:

Cell Telephone

Research information:

My main field of research is targeting the salt-sensitive high blood pressure. This particular kind of high blood pressure has been connected with a genetic component that is inherited from parents to offspring and that is usually exacerbated by high salt-intake. As a Geneticist Candidate and a Pharmacist, I am investigating the genes that might be involved in transmitting that genetic form of high blood pressure.

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Director, Laboratory of Genetics of Cardiac Diseases
Assistant professor
Faculty of Medicine
University of Ottawa Heart Institute

Contact information:

Office: 613-798-5555 (16341)
Office: 613-798-5555 (14559)
E-mail: ftesson@ottawaheart.ca
Website

Preferred method of contact:

Office Telephone

Research information:

Determination of genes involved in the development of heart failure. Determination of genes involved in obesity and diabetes.

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English and French

Dr.
Assistant professor
Faculty of Medicine
Cellular and Molecular Medicine

Contact information:

Office: 613-562-5800 (8068)
E-mail: ltrinkle@uOttawa.ca
Website

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E-mail

Research information:

The typical mammalian cell expresses thousands of proteins, over a third of which are regulated by the reversible addition of a phosphate group. My laboratory studies the targeting and regulation of PP1, one of the key enzymes in the cell that removes these phosphate groups. By studying this phosphatase in living cells using cutting edge fluorescence microscopy techniques and novel methods for identifying protein complexes, we can define its roles in diverse intracellular signalling pathways and how it may be disrupted in disease states such as cancer and diabetes.

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Corinne Boyer Chair in Ovarian Cancer Research
Full professor
Faculty of Medicine
Cellular and Molecular Medicine

Contact information:

Office: 613-737-7700 (70330)
E-mail: bvanderhyden@ohri.ca
Website

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E-mail

Research information:

Ovarian cancer, notably the cellular and molecular mechanisms that are important for the initiation and progression of ovarian tumours. Testing of novel therapeutics against ovarian cancer in women and in animal models of ovarian cancer. Transgenic (genetically modified) animals. Science education and outreach: Let's Talk Science program.

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Full professor
Faculty of Science
Biology

Contact information:

Office: 6135625800 x6886
Office: 6135625800 x2527
Cell: 613-204-2347
Home: 6138300115
E-mail: xxia@uottawa.ca
Website

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E-mail

Research information:

I study 1) how genes change, and how the interaction of gene products change, over geological time, 2) how mutation and selection.shape such changes, and 3) how to trace natural history back to time immemorial by identifying the footprints left by mutation and selection on DNA.

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