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Your search for "Animal physiology" returned the following 13 expert(s):

ALBERT, Paul R. »

CIHR/Novartis Michael Smith Chair in Neuroscience
Full professor
Faculty of Medicine
Medicine

Contact information:

Office: 613-562-5800 (8307)
E-mail: palbert@uOttawa.ca
Website

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E-mail, Office Telephone

Research information:

Our research addresses the role of the serotonin and dopamine systems in Depression, Anxiety, and Schizophrenia. In particular, our research focuses on genetic and environmental factors (such as early or late life stress) that determine the activity of these systems and the implications for brain function and behavior. We have identified specific gene polymorphisms, gene regulators and epigenetic alterations caused by stress that increase the risk of mental illness and affect the response to antidepressant treatments. Our current research is to develop animal models of these genetic alterations to identify their role in susceptibility to mental illness and as models to develop new treatments to attenuate the effects of stress, anxiety, or depression.

Other area of expertise: Mental Retardation

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BUI, Tuan »

Assistant professor
Faculty of Science
Biology

Contact information:

Office: 613-562-5800 ext 7888
E-mail: tuan.bui@uottawa.ca
Website

Preferred method of contact:

E-mail

Research information:

My research program focuses on understanding how our nervous system enables us to move. We identify neurons in the brain and in the spinal cord, and determine their exact roles in our everyday movements.

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English and French

MALER, Leonard »

Professor
Full professor
Faculty of Medicine
Cellular and Molecular Medicine

Contact information:

Office: 613-562-5800 (8189)
E-mail: lmaler@uOttawa.ca

Preferred method of contact:

E-mail

Research information:

Sensory systems are the gateway from the external world to our brains. They actively process raw sensory input and convert it into a form animals can use to guide themselves and interact appropriately. Sensory systems use feedback to optimize the analysis of important features of the environment. I study the role of feedback in sensory processing using an electric fish model.

Area(s) of expertise:

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Animal physiology

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MENNIGEN, Jan »

Assistant professor
Faculty of Science
Biology

Contact information:

Office: 613-302-6611
E-mail: jan.mennigen@uottawa.ca

Preferred method s of contact:

E-mail, Office Telephone

Research information:

Comparative Physiology of Metabolism ? ?I principally use two teleost research models, zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss) to comparatively study energy metabolism, using an integrated approach. This approach covers molecular, cellular and organismal aspects of energy metabolism, all of which integratively form the metabolic phenotype. A current research focus lies on the elucidation of epigenetic origins of metabolic phenotypes across ontogeny and generations, which in contrast to mammalian research models remains largely uncharacterized in lower vertebrates. In addition to providing comparative insight into epigenetic mechanisms governing the metabolic phenotype, the study of epigenetic mechanisms in fish models is especially applicable to three major areas addressed under this framework, which are outlined below. 1) Aquaculture In addition to being a valuable research model in the comparative physiology of metabolism, rainbow trout are the most important aquaculture species in Ontario. Following the recent sequencing of the rainbow trout genome, novel possibilities exist to address regulation and function of context-dependent epigenetic mechanisms in the metabolic phenotype. Focusing primarily on microRNAs, I am interested in how these molecular epigenetic mechanisms contribute to the metabolic phenotype in rainbow trout across ontogeny and at different levels of biological organization. In addition to providing insight into the evolution of microRNA mediated metabolic networks and function, the elucidation of these mechanisms will provide novel insight into the contribution of epigenetic mechanisms to rainbow trout specific phenotypes relevant to aquaculture. Examples include the implication of epigenetic mechanisms in mediating acute and sustained metabolic and growth effects of plant-based diets and the potential implication of epigenetic mechanisms in nutritional programming approaches. 2) Ecotoxicology Principally using the zebrafish model, Danio rerio, I am interested in the role of endocrine disrupting chemicals on the metabolic phenotype across ontogeny and generations either at baseline or in conjunction with environmental stressors experienced across ontogeny and generations. This represents an environmentally realistic scenario, as contaminants are subject to temporal variation due to regulation and continuing emergence of novel aquatic environments. A principal goal is to gain insight into germ-line dependent epigenetic mechanisms (principally DNA methylation) in the emergence of these phenotypes, and to develop epigenetic markers as improved prediction tools for EDC and aquatic contaminant exposure. 3) Teleost fish as models for metabolic disease ? Zebrafish are increasingly used as model systems for disease including metabolic disease. Taking advantage of this model, a specific research interest lies in the elucidation of transgenerational interaction of non-exclusive biological hypothesis of metabolic disease. A principal aim is to gain understanding of the integration of the three major biological hypothesis across ontogeny and generations in the emergence of metabolic disease: (1) The developmental origin of disease hypothesis ('Barker hypothesis') (2) the contribution of environmental endocrine disrupting chemicals ('metabolic disruptor hypothesis') (3) nutritional factors ('life-style hypothesis') This approach is aimed to gain insight into novel epigenetic determinants and the identification of novel molecular drug targets for metabolic disease.

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English and French , German

MERALI, Zul »

Contact information:

Office: 613-562-5800 (6005)
E-mail: sfperry@science.uOttawa.ca

Preferred method of contact:

E-mail

Research information:

My work focuses on the physiological adaptations enabling fish to survive stress in their environment. Of particular interest, is the involvement of stress hormones. Most recently, my research has been directed toward using fish as model systems for investigating mechanisms underlying human disease.

Area(s) of expertise:

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Animal physiology

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WEBER, Jean-Michel »

Full professor
Faculty of Science
Biology

Contact information:

Office: 613-562-5800 (6007)
Office: 613-562-5800 (6008)
Home: 613-565-6913
E-mail: jmweber@uOttawa.ca
Website

Preferred method of contact:

Office Telephone

Research information:

How humans and animals manage their reserves of energy. Storage, mobilization and use of metabolic fuel reserves. Human obesity.

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English and French

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