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Your search for "Developmental biology" returned the following 7 expert(s):

BUI, Tuan »


Assistant professor
Faculty of Science
Biology

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Office: 613-562-5800 ext 7888
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E-mail

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My research program focuses on understanding how our nervous system enables us to move. We identify neurons in the brain and in the spinal cord, and determine their exact roles in our everyday movements.

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EKKER, Marc »


Full professor
Faculty of Science
Biology

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Office: 613-562-5800 (2605)
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Research information:

Dr. Ekker's main research interests lie in the evolution and regulation of families of genes involved in embryonic development. He pursues the characterization of developmental genes in zebra fish and mice with a particular emphasis on the Dlx homeobox genes. The Dlx genes are studied more particularly in the context of forebrain and brachial arch development. Finally, the Ekker laboratory is using zebra fish as a model for Parkinson’s disease.

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ISMAIL, Nafissa »


Assistant professor
Faculty of Social Sciences
School of Psychology

Contact information:

Office: 613-562-5800 ext. 4176
Cell: 613-617-2270
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Website

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Office Telephone

Research information:

Critical periods of development are marked by important physiological and neural changes. These changes shape behavior and set the stage for the vulnerability of diseases in adulthood. Exposure to stressors during these critical periods can have profound long-lasting effects on brain function and can increase the risk of psychopathology later in life. While it is possible to reduce exposure to certain environmental stressors, other stressors, such as sickness, are almost unavoidable. My research interests are to investigate the neurochemical mechanisms through which immune challenge and hormones during the prenatal and pubertal periods alter behavior. The behavioral outcomes that I am examining are social behaviors, depression and cognition. I use small rodents, such as laboratory mice and rats, to gain mechanistic insight into these questions.

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KOSZYCKI, Diana »


Full Professor
Full professor
Faculty of Medicine
Psychiatry

Contact information:

Office: 613-722-6521 (6886)
Home: 613-526-0476
E-mail:

Preferred method s of contact:

E-mail, Home Telephone, Office Telephone

Research information:

Causes and treatments of anxiety disorders, including panic disorder, social anxiety disorder, generalized anxiety disorder. Cognitive Behavior Therapy, Interpersonal Therapy. Spirituality and mental health. Research on children at risk for anxiety disorders. Women's issues.

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MENNIGEN, Jan »


Assistant professor
Faculty of Science
Biology

Contact information:

Office: 613-302-6611
E-mail:

Preferred method s of contact:

E-mail, Office Telephone

Research information:

Comparative Physiology of Metabolism ? ?I principally use two teleost research models, zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss) to comparatively study energy metabolism, using an integrated approach. This approach covers molecular, cellular and organismal aspects of energy metabolism, all of which integratively form the metabolic phenotype. A current research focus lies on the elucidation of epigenetic origins of metabolic phenotypes across ontogeny and generations, which in contrast to mammalian research models remains largely uncharacterized in lower vertebrates. In addition to providing comparative insight into epigenetic mechanisms governing the metabolic phenotype, the study of epigenetic mechanisms in fish models is especially applicable to three major areas addressed under this framework, which are outlined below. 1) Aquaculture In addition to being a valuable research model in the comparative physiology of metabolism, rainbow trout are the most important aquaculture species in Ontario. Following the recent sequencing of the rainbow trout genome, novel possibilities exist to address regulation and function of context-dependent epigenetic mechanisms in the metabolic phenotype. Focusing primarily on microRNAs, I am interested in how these molecular epigenetic mechanisms contribute to the metabolic phenotype in rainbow trout across ontogeny and at different levels of biological organization. In addition to providing insight into the evolution of microRNA mediated metabolic networks and function, the elucidation of these mechanisms will provide novel insight into the contribution of epigenetic mechanisms to rainbow trout specific phenotypes relevant to aquaculture. Examples include the implication of epigenetic mechanisms in mediating acute and sustained metabolic and growth effects of plant-based diets and the potential implication of epigenetic mechanisms in nutritional programming approaches. 2) Ecotoxicology Principally using the zebrafish model, Danio rerio, I am interested in the role of endocrine disrupting chemicals on the metabolic phenotype across ontogeny and generations either at baseline or in conjunction with environmental stressors experienced across ontogeny and generations. This represents an environmentally realistic scenario, as contaminants are subject to temporal variation due to regulation and continuing emergence of novel aquatic environments. A principal goal is to gain insight into germ-line dependent epigenetic mechanisms (principally DNA methylation) in the emergence of these phenotypes, and to develop epigenetic markers as improved prediction tools for EDC and aquatic contaminant exposure. 3) Teleost fish as models for metabolic disease ? Zebrafish are increasingly used as model systems for disease including metabolic disease. Taking advantage of this model, a specific research interest lies in the elucidation of transgenerational interaction of non-exclusive biological hypothesis of metabolic disease. A principal aim is to gain understanding of the integration of the three major biological hypothesis across ontogeny and generations in the emergence of metabolic disease: (1) The developmental origin of disease hypothesis ('Barker hypothesis') (2) the contribution of environmental endocrine disrupting chemicals ('metabolic disruptor hypothesis') (3) nutritional factors ('life-style hypothesis') This approach is aimed to gain insight into novel epigenetic determinants and the identification of novel molecular drug targets for metabolic disease.

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English and French , German

TRUDEAU, Vance »


Vance TRUDEAU

University Research Chair in Neuroendocrinology
Full professor
Faculty of Science
Biology

Contact information:

Office: 613-562-5800 (6165)
Office: 613-562-5800 (6015)
E-mail:
Website

Preferred method s of contact:

E-mail, Office Telephone

Research information:

Control on reproduction and sexual development by the brain ("neuroendocrinology"). Effects of sex hormones and pollutants on reproduction in fish and frogs.Captive breeding and conservation of amphibians

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English and French

VANDERHYDEN, Barbara »


Barbara VANDERHYDEN

Corinne Boyer Chair in Ovarian Cancer Research
Full professor
Faculty of Medicine
Cellular and Molecular Medicine

Contact information:

Office: 613-737-7700 (70330)
E-mail:
Website

Preferred method of contact:

E-mail

Research information:

Ovarian cancer, notably the cellular and molecular mechanisms that are important for the initiation and progression of ovarian tumours. Testing of novel therapeutics against ovarian cancer in women and in animal models of ovarian cancer. Transgenic (genetically modified) animals. Science education and outreach: Let's Talk Science program.

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English only

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