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Your search for "Toxicology" returned the following 5 expert(s):
BRAND, Kevin »
Dr.
Assistant professor
Institute of Population Health
Contact information:
Office: 613-562-5800 (1852)
E-mail: kbrand@uOttawa.ca
Preferred method of contact:
Research information:
I specialize in methods for risk assessment and risk management, with a particular focus upon human health risks. I am particularly interested in the science policy interface that mediates between the synthesis of facts and the formulation of policy defining conclusions. Methods of particular interest include uncertainty analysis, applied decision analysis, demography, and health economics. I have applied these types of tools in the context of interpreting animal bioassay evidence in the support of regulatory determinations of chemical safety, and am currently applying demography approaches to the study of summary measures of population health (such as DALYs, QALYs, PEYLLs and alike).
Area(s) of expertise:
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- Applied statistics
- Decision analysis
- Epidemiology
- Health economics
- Health research
- Operations research
- Population health
- Toxicology
Language preference:
English only
MENNIGEN, Jan »
Assistant professor
Faculty of Science
Biology
Contact information:
Office: 613-302-6611
E-mail: jan.mennigen@uottawa.ca
Preferred method s of contact:
E-mail, Office Telephone
Research information:
Comparative Physiology of Metabolism ? ?I principally use two teleost research models, zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss) to comparatively study energy metabolism, using an integrated approach. This approach covers molecular, cellular and organismal aspects of energy metabolism, all of which integratively form the metabolic phenotype. A current research focus lies on the elucidation of epigenetic origins of metabolic phenotypes across ontogeny and generations, which in contrast to mammalian research models remains largely uncharacterized in lower vertebrates. In addition to providing comparative insight into epigenetic mechanisms governing the metabolic phenotype, the study of epigenetic mechanisms in fish models is especially applicable to three major areas addressed under this framework, which are outlined below. 1) Aquaculture In addition to being a valuable research model in the comparative physiology of metabolism, rainbow trout are the most important aquaculture species in Ontario. Following the recent sequencing of the rainbow trout genome, novel possibilities exist to address regulation and function of context-dependent epigenetic mechanisms in the metabolic phenotype. Focusing primarily on microRNAs, I am interested in how these molecular epigenetic mechanisms contribute to the metabolic phenotype in rainbow trout across ontogeny and at different levels of biological organization. In addition to providing insight into the evolution of microRNA mediated metabolic networks and function, the elucidation of these mechanisms will provide novel insight into the contribution of epigenetic mechanisms to rainbow trout specific phenotypes relevant to aquaculture. Examples include the implication of epigenetic mechanisms in mediating acute and sustained metabolic and growth effects of plant-based diets and the potential implication of epigenetic mechanisms in nutritional programming approaches. 2) Ecotoxicology Principally using the zebrafish model, Danio rerio, I am interested in the role of endocrine disrupting chemicals on the metabolic phenotype across ontogeny and generations either at baseline or in conjunction with environmental stressors experienced across ontogeny and generations. This represents an environmentally realistic scenario, as contaminants are subject to temporal variation due to regulation and continuing emergence of novel aquatic environments. A principal goal is to gain insight into germ-line dependent epigenetic mechanisms (principally DNA methylation) in the emergence of these phenotypes, and to develop epigenetic markers as improved prediction tools for EDC and aquatic contaminant exposure. 3) Teleost fish as models for metabolic disease ? Zebrafish are increasingly used as model systems for disease including metabolic disease. Taking advantage of this model, a specific research interest lies in the elucidation of transgenerational interaction of non-exclusive biological hypothesis of metabolic disease. A principal aim is to gain understanding of the integration of the three major biological hypothesis across ontogeny and generations in the emergence of metabolic disease: (1) The developmental origin of disease hypothesis ('Barker hypothesis') (2) the contribution of environmental endocrine disrupting chemicals ('metabolic disruptor hypothesis') (3) nutritional factors ('life-style hypothesis') This approach is aimed to gain insight into novel epigenetic determinants and the identification of novel molecular drug targets for metabolic disease.
Area(s) of expertise:
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Language preference:
English and French , German
MOON, Thomas »
Emeritus professor
Faculty of Science
Biology
Contact information:
Home: 613-233-6922
E-mail: tmoon@uOttawa.ca
Website
Preferred method of contact:
Research information:
My interests and expertise resides with how animals and in particular fish, adapt or adjust to their environment both in the short- (seasonally) and long- (evolutionary) terms. Recently my work has emphasized how toxic chemicals (man-made chemicals including PCBs and pharmaceuticals) found in aquatic environments impact the health, reproduction and fitness of fish species.Area(s) of expertise:
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Language preference:
English only
PICK, Frances Renata »
Coordinator of the Chemical and Environmental Toxicology Collaborative Programme / Coordonateur du programme de Toxicologie chimique et environnementale
Full professor
Faculty of Science
Biology
Contact information:
Office: 613-562-5800 (6364)
Office: 613-562-5800 (6365)
E-mail: frpick@uOttawa.ca
Website
Preferred method of contact:
Research information:
Freshwater ecology (lakes, rivers and wetlands) and water pollution problems (nutrients, metals, organic contaminants). Microbial ecology.
Area(s) of expertise:
(View other experts in this field)
Language preference:
English and French , some Spanish
TRUDEAU, Vance »
University Research Chair in Neuroendocrinology
Full professor
Faculty of Science
Biology
Contact information:
Office: 613-562-5800 (6165)
Office: 613-562-5800 (6015)
E-mail: vtrudeau@science.uOttawa.ca
Website
Preferred method s of contact:
E-mail, Office Telephone
Research information:
Control on reproduction and sexual development by the brain ("neuroendocrinology"). Effects of sex hormones and pollutants on reproduction in fish and frogs.Captive breeding and conservation of amphibians
Area(s) of expertise:
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Language preference:
English and French
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