Faculty of Medicine
Cellular and Molecular Medicine
Office: 613-562-5800 (8068)
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The typical mammalian cell expresses thousands of proteins, over a third of which are regulated by the reversible addition of a phosphate group. My laboratory studies the targeting and regulation of PP1, one of the key enzymes in the cell that removes these phosphate groups. By studying this phosphatase in living cells using cutting edge fluorescence microscopy techniques and novel methods for identifying protein complexes, we can define its roles in diverse intracellular signalling pathways and how it may be disrupted in disease states such as cancer and diabetes.
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